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Original Summaries of Selected CANCERLIT Abstracts.
Success Rates for Therapy of Ductal Carcinoma in situ (DCIS)

Last modified on: Tuesday, April 20, 1999 10:52:30
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One abstract in the September CANCERLIT update recorded the fifteen-year outcome of conservation surgery and radiotherapy for ductal carcinoma in situ (DCIS) at the University of Pennsylvania, Philadelphia (ICDB/95613281). There were 268 patients with 270 DCIS treated between 1968 and 1985 by complete gross excision of the primary tumor plus definitive breast irradiation. The tumor was detected by mammography alone in 113 cases (42%). There were 45 local failures (17%), with a median time to failure of 5.2 years. Among local recurrences there was invasive ductal carcinoma in 24 cases (53%) and intraductal carcinoma in 21 cases (47%). The authors concluded that while local failures occur after conservative surgery and radiotherapy, there is a high rate of long-term survival and freedom from distant metastases in DCIS patients. The authors concluded that the combined procedure is an acceptable alternative to mastectomy for appropriately-selected patients.

In contrast to the 17% local failure rate quoted above, a surgical paper claimed a 1% local recurrence rate for DCIS treated by mastectomy. The authors, from the Breast Center in Van Nuys, California, used what was termed glandular replacement therapy. This involved a combination of skin-sparing mastectomy and autologous tissue reconstruction (generally with a free transverse rectus abdominis flap). A circumareolar incision with a linear extension was used, so that the skin envelope remained intact allowing autologous tissue reconstruction with the new breast of almost the same size, shape, and texture as the breast that has been removed. The circular defect left by excision of the nipple-areolar complex is filled with skin transferred on the flap. Initially, this skin is used to monitor the flap, and later to reconstruct the nipple-areolar complex. Initially, the procedure costs more than radiotherapy. The authors point out that this is a one-time cost, whereas conservative treatment requires life-long mammography, about 40% can expect additional biopsies at some time in the future, somewhere in the region of 20% will experience a local recurrence. Since half of all local recurrences are invasive, there may be a mortality rate of 2-4% for DCIS patients treated conservatively.

October, 1995


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