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Original Summaries of Selected CANCERLIT Abstracts.
Effects of Altered Cohesion on Spatial Distribution of Cells
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
One of the special characteristics of cancer cells is an altered
cohesion when in contact with other cells. A study from the
University of Sheffield Medical School in the UK (Bury;
ICDB/95612242) looked at the idea that this altered cell behavior
might affect the spatial distribution of cell clumps within
cytospin preparations of material aspirated from breast lesions.
Of the 362 cytospin preparations of breast aspirates examined, 158
were benign and 204 malignant. Images were digitized, and 12
morphometric parameters were used to describe the spatial
distribution of cell clumps within these images. Ten parameters
showed significant differences between the benign and malignant
groups. Linear discriminant analysis, using all 12 parameters to
predict the presence of malignancy, correctly classified 298 cases
for an accuracy 82.3%, a sensitivity of 82.8%, and specificity
85.4%). Nine parameters also showed significant differences
between ductal and lobular breast tumors.
November, 1995
Copyright (c) 1994-2008, Information Ventures, Inc.
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