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Original Summaries of Selected CANCERLIT Abstracts.
Diet and Breast Cancer
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
Studies linking fat intake with breast cancer have come up with inconsistent results. One major impetus behind the Women's Health Study is to resolve this issue in a large population. There has been much skepticism as to whether the goal can be achieved. A recent small but randomized study (ICDB/95609422), using another way of approaching the issue suggests that dietary intervention is feasible. Eighteen African American, 8 Hispanic, and 17 White postmenopausal women were randomized into dietary intervention (I) and control (C) groups. The mean age of the two groups did not differ (C: 52.4 +/- 1.3 yr, n=21 and I: 53.8 +/- 1.1 yr, n=20). After 6 months of dietary instruction, the intervention group significantly reduced their fat intake from 31.1 +/- 1.9% (n=21) to 22.6 +/- 2.0% (n=19) of energy intake, whereas the control group's fat intake did not differ from baseline (baseline: 36.5 +/- 1.2%, n=19; 6 months: 34.8 +/- 1.9%, n=18). Total serum progesterone, estradiol and steroid hormone binding globulin levels remained the same in both groups; however, the percent non-protein binding estrogen of the intervention group decreased significantly after 6 months of a low-fat diet (p less than 0.001). This supports the hypothesis that a diet with about 20% energy from fat promotes a decrease in non-protein binding estrogen, which would probably reduce the eventual risk of breast cancer in postmenopausal women of all ethnic groups.
September, 1995
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