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Original Summaries of Selected CANCERLIT Records
Etiology of Childhood Acute Myeloid Leukemia (AML)
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
The abstract of a doctoral dissertation presented at the Ohio State
University (Steinbuch; ICDB/95615376), contained data on a survey
of a range of factors in the etiology of childhood acute myeloid
leukemia (AML). This case-control study described the preliminary
results of an analysis of a subset of 271 cases (eventually there
will be 525) and 322 controls. Interim analysis focused on
maternal exposures. Cases were obtained through the Children's
Cancer Group, and age- and race-matched regional population
controls were selected by random digit dialing. Information was
collected through telephone interviews with parents. Among the
statistically significant associations were occupational exposure
to soldering with an odds ratio (OR) of 4.3 or pesticides, OR 2.09,
the latter increasing with cumulative pesticide exposure by air
contact (trend p = 0.02). Postnatal exposure to rodenticides was
associated with an elevated OR of 1.80, and there was a 40% excess
risk of AML among children whose mothers had ever used marijuana.
An increased risk of AML was seen among children who had ever been
exposed to any X-rays for diagnostic purposes, with ORs between
2.20 and 4.64 (latter for back and spine). The limited sample
precluded a more thorough evaluation, which will be attempted in
the full study. This may lead to a better understanding of the
possible biologic mechanisms involved in the etiology of childhood
AML.
November, 1995
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