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Original Summaries of Selected CANCERLIT Records
Cigarette Smoking as a Risk Factor for Pancreatic Cancer
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
Pancreatic cancer presents a particularly difficult clinical
problem, since it is a tumor whose presence is seldom manifested
before the disease has become relatively advanced, and is then
unresponsive to treatment. A study from Columbia University, New York
(Neugut; ICDB/95613583), presented data from the Surveillance,
Epidemiology, and End-Results (SEER) Program for the time
period from January 1, 1973, through December 31, 1990. Little
is known about risk factors for pancreatic carcinoma, so its
occurrence as a second primary malignancy was investigated.
The observed number of cases was divided by the expected number
to estimate the relative risk (RR) of pancreatic cancer as a
second primary cancer. This pancreatic cancer risk was elevated
following lung cancer for both men and women (RR 1.3 and 2.5),
and head and neck cancers (RR 1.8) and bladder cancer (RR 1.5)
in women, but not in men. There was a significant elevation
following prostate cancer (RR 1.2), and a decreased risk
following lymphoma in men (RR 0.2). It appeared that risk for
second primary pancreatic cancer is increased following
tobacco-related malignancies, particularly in females. This
supports a role for cigarette smoking as a risk factor for
pancreatic cancer, and suggests there may be a stronger effect
in women.
November, 1995
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