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Original Summaries of Selected CANCERLIT Records
Lung Cancer in African-Americans and Caucasians
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
Mutations that lead to loss of activity of the CYP2D6 gene, which
codes for an enzyme that converts tobacco-related carcinogens to
their active toxic forms, have been hypothesized to decrease lung
cancer risk. A report from the University of Southern California
School of Medicine (ICDB/95609445), described a case-control study
of 343 African-American and Caucasian cases with lung cancer and
712 population controls in Los Angeles county. The odds ratio for
any mutant of CYP2D6 in the cases was 0.77, but the presence of any
mutant was associated with significantly decreased lung cancer risk
only for those smokers with a history of less than 40 pack-year
(odds ratio 0.57), but not for heavier smokers (odds ratio 1.04).
When the numbers were looked at by race, loss of active gene allele
was associated with a lower lung cancer risk among African-American
smokers (odds ratio 0.54), as for the total population, but the
mutant genes were less common (p = 0.001) among African-Americans
(0.15) than among Caucasians (0.22).
October, 1995
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