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Original Summaries of Selected CANCERLIT Records
Breast Cancer Differences Between African Americans and Caucasians
Last modified on:
Tuesday, April 20, 1999 10:52:30
Copyright © 1994-2008, Information Ventures, Inc.
A report from the Michigan Cancer Foundation-Meyer L. Prentis
Comprehensive Cancer Center of Metropolitan Detroit was presented
at the AACR Meeting (ICDB/95613571). The study population consisted
of 10,502 women (82% whites, 18% blacks), diagnosed with breast
cancer from 1988 through 1992, and identified through the
population-based Metropolitan Detroit Cancer Surveillance System.
A racial difference was seen in that black women were more likely
to present with regional or distant disease (44%) than were white
women (36%), and black women (30%) were more likely to have nuclear
Grade III or IV disease at biopsy than were white women (18%).
After controlling for age, stage, and tumor grade, the relative
risk of dying was 1.4 times greater for blacks than for whites.
Socioeconomic factors (SES) are obvious candidates for contributing
to this racial difference. However, additional adjustment for a
census-derived SES variable reduced the relative risk of mortality
only slightly to 1.3. Characteristics of the tumor and SES factors
explain about 60% of the difference in case fatality between black
and white women. The results are consistent with others reported
earlier by Eley et al (Journal of the American Medical Association
272:947-54, 1994), in that black women had a modestly higher risk
of death, relative to white women, after accounting for tumor stage
and grade at diagnosis and sociodemographic factors.
October, 1995
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