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Original Summaries of Selected CANCERLIT Records
Biodegradable Materials as Vehicles for Drug Delivery
Last modified on:
Tuesday, April 20, 1999 10:52:32
Copyright © 1994-2008, Information Ventures, Inc.
Biodegradable has long been a catchword in environmental matters,
but now it also appears to be on the threshold of widespread
clinical use. Several database entries in the September 1995
CANCERLIT update refer to preclinical studies of the use of
biodegradable materials as vehicles for drug delivery. One such
study in rats, was carried out at the University of Colorado Health
Sciences Center in Denver (ICDB/95609603). Sustained release
cisplatin from a biodegradable polymer (OPLA-Pt) implanted
intracranially was used to eradicate rat brain tumors. Tumor
control animals had a mean survival of 26 days increasing in the
regular intraperitoneal-platinum-treated group to 30 days (increase
not significant). With increasing doses of OPLA-Pt, on the other
hand, survival was 34 days in the 0.5 mg/m2 group, 39 days in the
1.0 mg/m2 group and 47 days in the 2.0 mg/m2 treated group (p =
0.0002).
October, 1995
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