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Original Summaries of Selected CANCERLIT Records
A Novel Approach to Regional Intrahepatic Chemotherapy with Fluorodeoxyuridine
Last modified on:
Tuesday, April 20, 1999 10:52:32
Copyright © 1994-2008, Information Ventures, Inc.
Liver metastases from colorectal cancer present a clinical
challenge, and regional chemotherapy to treat them is associated
with regional toxicity and requires a surgically-implanted pump.
A novel approach to regional intrahepatic chemotherapy with
fluorodeoxyuridine (FUdR) at Johns Hopkins University, Baltimore
(ICDB/95609615), used copolymer discs comprised of 30% FUdR by
weight in a biodegradable polyanhydride copolymer. These were
implanted in the livers of an experimental rat model of hepatic
colorectal cancer. Complete responses within 14-28 days were seen
in 30% of drug-treated tumors, compared to 0% in controls. No
systemic or regional toxicity was noted in treated rats which had
normal weight gain and normal liver function tests.
October, 1995
Copyright (c) 1994-2008, Information Ventures, Inc.
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