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The CancerWeb Report, What's New In Cancer
Childhood Cancers: December 1995
Last modified on:
Tuesday, April 20, 1999 12:03:10
Copyright © 1994-2008, Information Ventures, Inc.
Childhood Cancers -
A group of nervous cell tumors usually originating in the chest
wall, around the spine and pelvis and limbs called peripheral
primitive neuroectodermal tumors (pPNETs) frequently carry a poor
prognosis. An article in the November, 1995 issue of the Journal of
Clinical Oncology from the Memorial Sloan-Kettering Cancer
Center, New York, deals with chemotherapy in this disease. In
these children with poorly responding tumors, very high-dose, 6-
drug, short-term chemotherapy (the P6 protocol) was promising.
For 24 patients with nonmetastatic disease, there was 77.1%
survival at a median follow-up time of 26 months. In metastatic
disease, 6 of 6 with lung metastases achieved complete remission
of lung disease; bone disease was less amenable. Toxicity,
consisting of myelosuppression and mucositis, was manageable.
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