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The CancerWeb Report, What's New In Cancer
Colon Cancer: December 1995
Last modified on:
Tuesday, April 20, 1999 12:03:10
Copyright © 1994-2008, Information Ventures, Inc.
DNA Adducts in Colorectal cancer -
Colorectal cancer may be attributed in some measure to
environmental carcinogens, especially those in the diet. These
carcinogens would be expected to react with cellular DNA
producing what are called DNA adducts that lead to damage and
mutations. A study from Laennec Hospital in Paris, and the
Laboratory of Food Toxicology and Safety in Toulouse, France,
reported in the December 1, 1995 issue of Cancer Research, looked for
such colonic DNA adducts. The level was significantly higher in
the nontumoral colon mucosa from patients with colon cancer (91.3
+- 95.6 /10 9), than in the mucosa from control patients with
benign sigmoiditis (4.7 +- 6.0 adducts/10 9 nucleotides), or in
the tumoral tissue (6.15 =- 8.2 x 10 9) from the same patients.
This is the first such finding, indicating that measurement of
adducts may serve as an early warning test of potential later
cancer development.
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