Electromagnetic Field Toxicology Reporter

Evaluation and Assessment of Extremely Low Frequency EMF Bioeffects
Volume 3, Number 1, March 2001

Mechanistic Studies

by Robert B. Goldberg, Ph.D., Editor

Summary

This article discussed reports in the areas of DNA damage, gene expression and calcium ion flux. Among DNA-related articles was a Swedish study of the effects on the brains of mice exposed outdoors to the field from a 50-Hz transmission line. Also included were studies of the effects on leukocytes from male human volunteers exposed to ELF magnetic fields for 1 hour, and bacterial DNA repair. Effects of ELF EMF on gene expression were evaluated in human HL-60 and mammary epithelial cells and a transformed mouse fibroblast cell line. The hypothesis that EMFs can affect circadian rhythms, which in turn affect oscillations in gene expression, was discussed. The relationship of oscillations and spiking of free calcium ion concentrations in cultured cells and ELF EMF exposure was the topic of two papers discussed in this issue. Other papers presented data on intracellular levels of calcium and ornithine decarboxylase activity in the brains of rats exposed in vivo to amplitude-modulated RF radiation. [twelve pages, 17 references].

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