Electromagnetic Field Toxicology Reporter

Evaluation and Assessment of Extremely Low Frequency EMF Bioeffects
Volume 3, Number 2, June 2001

Cellular Effects

by Robert B. Goldberg, Ph.D., Editor

Summary

Several groups have investigated possible mechanisms for an EMF cancer association by looking for increased DNA damage when isolated cells are exposed to EMF in conjunction with known mutagenic or DNA-damaging agents. Some groups have found damaging enhancing effects, particularly using comet gel assays, while others have found no effect. Researchers at Michigan State University reported that 60-Hz fields can block chemically-induced differentiation in a murine Friend erythroleukemia cell line. Another group showed that 50-Hz fields can enhance the growth rate of rat glioma cells. Two of three reports on EMF-induced gene expression produced negative results, while the third described a reversible EMF effect on expression of the adhesion molecule CD44s in rat astrocytes which was dose- and time-dependent. EMF-induced changes at the cell membrane level were supported by studies of liposomes (artificial membrane vesicles) that showed altered permeability which may reflect conformational changes in lipid membrane components.

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