Electromagnetic Field Toxicology Reporter

Evaluation and Assessment of Extremely Low Frequency EMF Bioeffects
Volume 1, Number 2, June 1999

Basic Mechanisms

by Robert B. Goldberg, Ph.D., Editor

Summary

One research group examined the expression of a large array of randomly sampled genes in experimental and control human promyelocytic leukemia cells following exposure to 60 Hz magnetic fields or X-rays. Two papers are discussed which attempted to show increased transcription in response to exposure to magnetic fields and compared with a third paper looking at epidermal polyamine concentrations and metabolism in female mice. Other papers reviewed looked at potential interactions with protein kinase-C activity and the protein-tyrosine kinase-dependent signal transduction pathway. Acceleration of electron transport from cytochrome C to the enzyme, cytochrome oxidase, the effects of 50-Hz EMFs on hepatic and pulmonary phase I and II drug-metabolizing enzymes, and the effects of a pulsed electromagnetic field on production of cytokines, are other topics discussed. Several articles examined aspects of calcium ion flux, including the relationship to cyclic nucleotide concentrations in human cells. This article concludes with a discussion of a Russian proposal that splitting of excited states of bound ions generated by weak static fields might be modulated by ELF time-varying magnetic fields to produce biological effects. [six pages, 21 references].

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