Electromagnetic Field Toxicology Reporter

Evaluation and Assessment of Extremely Low Frequency EMF Bioeffects
Volume 2, Number 4, December 2000

Mechanistic Studies

by Robert B. Goldberg, Ph.D., Editor

Summary

A number of potential mechanisms of action of EMFs have been proposed in the literature. The major ones are modulation of internal calcium equilibria through effects on ion channels, with consequent repercussions brought about through signal transduction pathways, alterations in gene expression, free radical-mediated processes that produce active oxygen species leading to macromolecular damage, and action on cellular components (magnetosomes) that respond to magnetic fields. We discuss these mechanisms and several reports testing them. Three articles are reviewed which involved studies of the potential effects of EMFs on gene expression, including induction of heat shock proteins, a typical response to a variety of stress factors, antioxidant enzymes and lipid peroxidation levels. [five pages, 16 references].

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