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Findings from animal and human studies relating to associations between chrysotile (12001295) asbestos exposure and malignant pleural mesothelioma were considered. Specific topics addressed included: epidemiological data (gas mask studies; fiber type risk comparisons); available animal data; the Stanton and amphibole hypotheses (lung content studies; pleural content studies); contribution of chrysotile asbestos to pleural mesothelioma incidence (potency of chrysotile; proportion of mesotheliomas due to asbestos; and production and use of asbestos in the United States); and conclusions concerning the contribution of chrysotile asbestos to mesothelioma incidence. Studies indicated that: chrysotile asbestos is a potent cause of pleural mesothelioma; the potency of chrysotile asbestos is similar to amphibole asbestos; the large majority of mesothelioma is attributable to asbestos exposure; and chrysotile asbestos is the major fiber type used worldwide. The authors conclude that based on this evidence, chrysotile asbestos must be considered the main contributor to pleural mesothelioma causation in humans in the United States and other countries in which it has been the predominant fiber type.
American Journal of Industrial Medicine, 30(3):252-266, 1996. (110 references)
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