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A relationship between bipyridine exposure during the manufacture of paraquat and photodamage and skin cancer was reported. Exposed workers from 28 paraquat factories in Taiwan were examined for skin lesions. Histological examination showed that selected workers had actinic keratosis (AK). Solar lentigo, AK, squamous cell carcinomas (SCC) in-situ coexisting with AK, and SCC were also identified among affected workers. No history of other risk factors was found among the affected workers. Two thirds of the paraquat factories produced paraquat from bipyridines after processing in open areas, resulting in heavy worker exposure. A trend for association between severity of lesions and heavy exposure was observed. The authors conclude that the strong correlation between photodamage and bipyridine exposure may be due to a synergistic action between a solar effect and bipyridine exposure.
International Journal of Dermatology, 34(7):466-469, 1995. (11 references)
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