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A study was conducted to evaluate the frequency of contact sensitization to the preservative Bioban-P-1487 (CAS 37304884) and its components when included in a standard patch test series. Bioban is a preservative consisting of two active ingredients 4-(2-nitrobutyl)-morpholine (NM) and 4,4'-(2-ethyl-2-nitro-1,3-propanedyl)-bis-morpholine (NDM) in a 70:20 proportion. A total of 1,102 consecutive patients with contact dermatitis were patch tested with Bioban or its components at an occupational health and dermatology clinic. Positive reactions to Bioban were seen in 17 patients (1.5% of the total population). Twelve of these were patch tested with NM and NDM in 95.5% ethanol. NM or NDM produced positive responses in four subjects. Two patients reacted to both NM and NDM, one to NM only, and one to NDM only. The authors conclude that contact allergy to Bioban is not uncommon in patients consecutively evaluated with patch tests. It is difficult, however, to draw any conclusions as to the sensitizing capability of the two ingredients. NM is present at higher concentrations than NDM in Bioban; however, the actual difference may even be greater as NDM appears to decompose into NM in aqueous solutions, such as in water based metalworking fluids.
Contact Dermatitis, 35(3):141-145, 1996. (7 references)
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