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Results from in depth analyses focusing on the relation between lung cancer and occupational exposure to carbon-black (1333864) pigments were presented. Detailed job histories were obtained from 857 incident cases with histologically confirmed lung cancer (359 squamous cell carcinomas; 167 adenocarcinomas; 159 oat cell carcinomas; and 172 other cell types or unclassified) as well as from 1,360 other cancer cases and 533 population controls. Occupations selected to correspond to various carbon-black exposure concentrations included: printing press operators and painters (low); rubber bonding and cutting occupations (medium); and paint mixers and rubber tire buffers and retreaders (high). Logistic regression analyses were adjusted for smoking and other occupational and nonoccupational potential confounders. While no significant increase in lung cancer risk was observed with relatively low exposure to carbon-black, some increase in risk for all lung cancers was detected with relatively high exposure. Individuals with relatively high exposure had a significantly greater risk of oat cell carcinoma using either cancer or population controls. The authors conclude that, while the available evidence for a role of carbon-black as a lung carcinogen is not definitive, these findings provide some support for an association between exposure to carbon-black and lung cancer.
American Journal of Industrial Medicine, 30(3):285-292, 1996.(30 references)
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