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Cases of biliary and pancreatic cancer in association with exposure to trichlorinated hydrocarbon solvents were reported. Three men (aged 45 years, 35 years, and 41 years) developed cholangio, ampullary, and pancreatic cancer after prolonged and heavy exposure to chlorinated hydrocarbon solvents for 4 years or less. The histories of two of the patients included direct skin contamination with trichloroethane (79005) or trichloroethylene (79016); they had exposure to other potential carcinogens as well. The other patient, who was exposed to trichloroethane and perchloroethylene (127184), had a strong family history of cancer. Two of the patients died. Other cases and evidence from recent literature were considered. The author concludes that exposure to trichlorinated hydrocarbon solvents is a risk factor for the development of biliary and pancreatic cancer; improved work practices and heightened physician awareness are recommended.
American Journal of Industrial Medicine, 30(3):341-342, 1996. (10 references)
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