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An analysis was conducted on peripheral blood lymphocyte cultures of workers who were exposed to uranyl compounds. Blood samples were collected from 116 smokers and 80 nonsmokers employed at a nuclear fuel facility. Smokers and nonsmokers exposed to uranyl showed significantly increased sister chromatid exchanges (SCEs) over control groups of smokers and nonsmokers. In the exposed group, the mean SCE rate per cell was 9.86 in nonsmokers and 10.56 in smokers. Corresponding values in the control groups were 3.52 SCEs/cell for nonsmokers and 5.42 SCEs/cell for smokers. The mean lung dose from uranium was 95.3 and 90.8 milliseiverts in nonsmokers and smokers, respectively. The authors conclude that there is evidence for the clastogenic effects of uranium in workers and recommend a detailed study of this high risk group on mutagenic effects from radiation exposure using a battery of protocols.
Mutation Research, 347(1):31-35, 1995. (34 references)
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